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Interventions to alleviate side effects are needed to reduce symptom burden, enhance quality of life and functional capacity, and improve adherence to therapy ().

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Two other meta-analyses were identified that focused on side effects of tamoxifen and summarized data from both prevention and treatment trials.

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In 1998, the National Cancer Institute (NCI) funded a large research study designed to determine whether tamoxifen would reduce the incidence of breast cancer in healthy women known to be at high risk.

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