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Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease induced
by repeated blows to the head. It is associated with the development of dementia
also known as dementia pugilistica or punch-drunk syndrome. It is characterized
by cognitive decline, mood disorders, and Parkinsonism. It is a very rare
condition. It has been found in the brains of people who played contact sports,
such as football, as well as others. In CTE, a protein called tau forms clumps
that slowly spread throughout the brain, killing brain cells. Approximately 1%
of the population of developed countries experiences CTE each year.

Some signs and symptoms of CTE are impulsive behavior, difficulty
thinking Cheap
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planning & carrying out tasks, short-term memory loss, emotional
instability, substance abuse, and suicidal thoughts or behavior etc.
Additionally, there are some suspected symptoms of CTE such as irritability,
speech & language difficulties Cheap
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sense of smell, vision & focusing problems, dementia, motor impairment
(difficulty making, tremor, loss of muscle movement, weakness or rigidity) and
aggression etc.

According to study Cheap
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Pipeline Review, H2 2018 some of the major companies that are working in the
chronic traumatic encephalopathy are Eustralis Pharmaceuticals Ltd, Prothena
Corp Plc, Tetra Discovery Partners LLC.

There are three stages of CTE. The first stage is characterized by affective
disturbances and psychotic symptoms. In the second stage, social irritability,
erratic behavior, memory loss and initial symptoms of Parkinson disease are
present. Moreover, the third stage is described as general cognitive
dysfunction: it is often accompanied by Parkinsonism along with speech and gait
abnormalities.

CTE is found mostly in people who have experienced repeated blunt force
trauma to the head. It can occur most commonly in auto accidents Cheap
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and military personnel, who survived explosions or other head trauma. The
primary risk factor of CTE is repetitive head trauma. Some tips are involved to
reduce the risk of potential head injury such as wearing a helmet while playing
sports (baseball, ice hockey, rugby, alpine skiing, and snowboarding) and
wearing a helmet while riding a bicycle, motorcycle, rollerblading or engaging
in any board sports etc.

There is currently no reliable way to diagnose CTE. Diagnose can be seen only
upon inspection after death or autopsy. However Cheap
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a test for CTE that can be used while people are alive. These tests include
neurological tests and brain-imaging tests. In neurological tests include
reflexes, coordination, sense of sight & hearing, balance, muscle tone &
strength, ability to get up from a chair and walk across room and
speech-language-cognition including short & long-term memory etc. In brain
imaging tests include magnetic resonance imaging (MRI), positron emission
tomography, event-related potentials & quantitative electroencephalography
and single tone emission computerized tomography. MRI test involves many tests:
susceptibility weighted imaging Cheap
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resonance spectroscopy. There are some homemade treatments are involved in a
calming environment, modified tasks, reassuring responses, regular exercise,
nighttime rituals, and games & thinking activities etc.

Some drugs are used in relaxing of CTE, which is; cannabidiol,
EUC-001 Cheap
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antibodies to inhibit tau for neurology, PU-AD, and TDP-101. CTE has been
characterized by widespread TDP-43 and beta-amyloid. TDP-43 is involved in
regulating translation in mitochondrial RNA in the brain. Beta-amyloid peptides
have diagnostic and prognostic utility for a broad number of neurodegenerative
disorders.

In 2018, it is estimated that a new medication ST266 will be developed for
nasal spray administration of the anti-inflammatory agent. ST266 medicine is
derived from processed placental cells. It is used to protect nerves in the eye
or brain through the nose. As well as imaging of amyloid and tau proteins will
aid in diagnosis. It is estimated that neuropsychological tests, brain imaging,
and biomarkers will be useful for the diagnosis of CTE.

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